Who are the patients with extrapulmonary tuberculosis?
Inês Sanchesa,, , Aurora Carvalhob,c, Raquel Duarted,b,e,c
a Servi??o de Pneumologia, Centro Hospitalar e Universit??rio de Coimbra- Hospital Geral, Coimbra, Portugal
b Servi??o de Pneumologia, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal
c Centro de Diagn??stico Pneumol??gico de Vila Nova de Gaia, Vila Nova de Gaia, Portugal
d Departamento de Epidemiologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
e Instituto de Sa??de Publica, Universidade do Porto, Portugal
Abstract
Introduction

Tuberculosis (TB) remains a major global public health problem and 20% of all cases are extrapulmonar. The purpose of this study was to identify risk factors associated with extrapulmonar tuberculosis.

Methods

We carried out a transversal study which included all patients with extrapulmonary tuberculosis registered in a TB reference center in northern Portugal, between January 2008 and January 2012. We evaluated demographic data, comorbidities, BCG vaccination and previous tuberculosis treatments. Multivariable logistic regression was used to identify independent risk factors (p < 0.05).

Results

Among the 386 patients studied, 260 (67.4%) had pulmonary tuberculosis (PTB) and 126 (32.6%) extrapulmonary TB (EPTB). Age over 40 years old (OR = 2.09; 95%CI: 1.29–3.38), female gender (OR = 1.63; 95%CI = 1.02–2.6) and HIV infection (OR = 2.72, 95%CI = 1.25–5.93) were independent risk factors for EPTB. Alcoholism (OR = 2.22, 95%CI: 1.00–4.95) was associated with higher risk for PTB. Previous liver disease (OR = 22.30; 95%IC: 1.89–263.57) was an independent risk factor for peritoneal TB. HIV co-infection (OR = 12.97; 95%IC: 1.71–48.42) and the presence of previous TB treatment (OR = 7.62; 95%IC: 1.00–57.9) increase the risk of disseminated disease.

Conclusion

We identified independent risk factors for EPTB. Recognizing risk factors associated with EPTB is essential for suspicion of disease and may help make an accurate diagnosis.

Keywords
Extrapulmonar tuberculosis, Risk factors, HIV co-infection

Metrics

  • Impact Factor: 1.560(2016)
  • 5-years Impact Factor: 1,100
  • SCImago Journal Rank (SJR):0,29
  • Source Normalized Impact per Paper (SNIP):0,685