Evaluation of the oxidant and antioxidant balance in the pathogenesis of Chronic Obstructive Pulmonary Disease

Cristóvão, C.; Cristóvão, L.; Nogueira, F.; Bicho, M.;
Next Document Rev Port Pneumol. 2013;19:70-5.

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is one of the most common chronic diseases and a major cause of morbility and mortality. An imbalance between oxidants and antioxidants (oxidative stress) has been proposed as a critical event in the pathogenesis of COPD. The increased oxidative stress in patients with COPD is the result of exogenous oxidants namely pollutants and cigarette smoke as well as endogenous oxidant production during inflammation. The aim of the present study was to clarify the hypothesis about the presence of an imbalance between oxidants and the antioxidant defences associated to COPD. In this study, we evaluated a biomarker of oxidative stress (malondialdehyde, a lipid peroxidation derived product) and non-enzymatic antioxidants (vitamin C and the sulphydryl groups) in COPD patients and healthy controls. The marker of oxidative stress was found to be significantly (p < 0,001) higher in COPD patients when compared with the control group. No age dependent changes in the plasma levels of lipid peroxidation products were found. COPD patients had a significant (p < 0,001) decrease in antioxidant status compared with control group. Our results show that oxidative stress is an important pathophysiologic change in COPD.

Keywords: Chronic obstructive pulmonary disease. Oxidative stress. Lipid peroxidation. Antioxidants.

C. Cristóvão a, , L. Cristóvão bcde, F. Nogueira a, M. Bicho e,

a Serviço de Pneumologia, Centro Hospitalar de Lisboa Ocidental, Hospital de Egas Moniz, Lisboa, Portugal
b Faculdade de Ciências Biomédicas, Universidade Lusófona de Humanidades e Tecnologias de Lisboa, Lisboa, Portugal
c Faculdade de Engenharia e Ciências Naturais, Universidade Lusófona de Humanidades e Tecnologias de Lisboa, Lisboa, Portugal
d Unidade de Biotecnologia Ambiental, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Lisboa, Portugal
e Laboratório de Genética, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal